For most of the NSAIDs the pharmacological activity reside in the (S)-enantiomers with their (R)-enantiomer of virtually inactive. Majority of the profens are marketed as racemic mixtures. Ketoprofen has one stereogenic center in the side chain and hence exists as mirror-image twins. The patches have been shown to provide rapid and sustained delivery to underlying tissues without significantly increasing levels of drug concentration in the blood when compared to the traditional oral administration. Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of proinflammatory prostaglandin precursors. with carbon-oxygen double bond) by carbonyl reducing enzymes (CREs). Ketoprofen undergoes metabolism in the liver via conjugation with glucuronic acid ( glucuronidation) by UGT enzymes, hydroxylation of the benzoyl ring by the CYP3A4 and CYP2C9 enzymes, and reduction of its ketone moiety (a carbonyl functional group, i.e. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in fetuses that result in low amniotic fluid. There is evidence supporting topical ketoprofen for osteoarthritis but not other chronic musculoskeletal pain. Ī 2013 systematic review indicated "The efficacy of orally administered ketoprofen in relieving moderate-severe pain and improving functional status and general condition was significantly better than that of ibuprofen and/or diclofenac." A 2017 Cochrane systematic review investigating ketoprofen as a single-dose by mouth in acute, moderate-to-severe postoperative pain concluded that its efficacy is equivalent to drugs such as ibuprofen and diclofenac. Dr Stanley G Rockson, of Stanford University is leading these researches.
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Animal trial and some human trials have shown significant improvement over placebo control.
Trials are going on for using this drug along with ibuprofen for management of lymphedema. Ketoprofen can also be used for treatment of some pain, especially nerve pain such as sciatica, postherpetic neuralgia and referred pain for radiculopathy, in the form of a cream, ointment, liquid, spray, or gel, which may also contain ketamine and lidocaine, along with other agents which may be useful, such as cyclobenzaprine, amitriptyline, acyclovir, gabapentin, orphenadrine and other drugs used as NSAIDs or adjuvant, atypical or potentiators for pain treatment. Ketoprofen topical patches are being used for treatment of musculoskeletal pain. Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. It was patented in 1967 and approved for medical use in 1980. It acts by inhibiting the body's production of prostaglandin. Check out the podcast and grab the Tile app.Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. Nelson demonstrates a cool device that works with an app on your smart phone to help you find those lost items. Jessica shows us iFaxfrom the Apple App Store that helps you send faxes from your mobile device.
Cool Picks This Week Include: iFax for iOS But, what about an app that helps you do more than just dictation? See how much you can do with one of the team’s latest finds. Look Mom! No hands!ĭictation apps are available now in just about all platforms and with many virtual assistants. Check it out here to get an idea of some of the apps discussed. The team discusses some amazing apps that have been developed for these incredible AR glasses. Augmented Reality Glasses Continue to Produce Accessible AppsĪ year ago Micro Soft announced a new device which they called Hololens.
Topics discussed on this week’s show include: The Price of Braille Reading Devices Continues to Become More AffordableĬheck out the team’s view on the “Canute” and how it is making believers of non-Braille readers like Joel. These answers and more are just waiting for you to press play and listen. Join Joel, Jessica, and Nelson as they share their opinions on whether or not a companies reputation should influence their decision on what accessible technology to buy. This week the Cool Blind Tech Team discusses some of the important questions surrounding the headlines in the tech world.
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